SNHG4

Chr 5

small nucleolar RNA host gene 4

Also known as: NCRNA00059, U19H

NCBI Gene: 724102ENSG00000281398
33
ClinVar variants
15
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— SNHG4
📋
ClinVar Variants
15 Pathogenic / Likely Pathogenic· 16 VUS of 33 total submissions
Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

33 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic14
Likely Pathogenic1
VUS16
Likely Benign1
Benign1
14
Pathogenic
1
Likely Pathogenic
16
VUS
1
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
14
0
14
Likely Pathogenic
0
0
1
0
1
VUS
1
0
15
0
16
Likely Benign
0
0
1
0
1
Benign
0
0
1
0
1
Total1032033

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

SNHG4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network.
Dong Q et al.·J Exp Clin Cancer Res
2023
The Regulatory Mechanisms and Clinical Significance of Lnc SNHG4 in Cancer.
Pourghasem N et al.·Curr Pharm Des
2022Review
Long non-coding RNA SNHG4 aggravates cigarette smoke-induced COPD by regulating miR-144-3p/EZH2 axis.
Song B et al.·BMC Pulm Med
2023
lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis.
Zhou Z et al.·Aging (Albany NY)
2021
LncRNA SNHG4 promotes the proliferation, migration, invasiveness, and epithelial-mesenchymal transition of lung cancer cells by regulating miR-98-5p.
Tang Y et al.·Biochem Cell Biol
2019
Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
Qiu J et al.·Cancer Med
2023
Expression and Regulatory Roles of Small Nucleolar RNA Host Gene 4 in Gastric Cancer.
Pourghasem N et al.·Curr Protein Pept Sci
2023
The prognostic value of lncRNA SNHG4 and its potential mechanism in liver cancer.
Jiao Y et al.·Biosci Rep
2020Functional
SP1-mediated upregulation of lncRNA SNHG4 functions as a ceRNA for miR-377 to facilitate prostate cancer progression through regulation of ZIC5.
Wang ZY et al.·J Cell Physiol
2020
The siRNA-mediated knockdown of SNHG4 efficiently induced pro-apoptotic signaling and suppressed metastasis in SW1116 colorectal cancer cell line.
Khajehdehi M et al.·Mol Biol Rep
2023
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Small nuclear ribonucleoprotein polypeptide B2 regulated by SNHG4/miR-204-5p axis inhibits ferroptosis to aggravate the progression of hepatocellular carcinoma.
Guo J et al.·Discov Oncol
2025🔓 Open Access
Tumor-derived exosomal lncRNA SNHG4 promotes triple-negative breast cancer progression by targeting XPO5.
Wang ZW et al.·Front Oncol
2025🔓 Open Access
LncRNA SNHG4 Regulates Lipid Metabolism and Inflammation in Non-Alcoholic Fatty Liver Disease by Targeting miR-34b-5p/XIAP Axis.
Ding Y et al.·Turk J Gastroenterol
2025🔓 Open Access
Long noncoding RNA SNHG4 promotes glioma progression via regulating miR-367-3p/MYO1B axis in zebrafish xenografts.
Zhang Y et al.·Hum Cell
2025🔓 Open AccessFunctional
lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis.
Cheng Z et al.·Oncol Res
2025🔓 Open Access
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools