SNHG32

Chr 6

small nucleolar RNA host gene 32

Also known as: C6orf48, D6S57, G8

NCBI Gene: 50854ENSG00000204387

Predicted to enable double-stranded RNA binding activity. Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.89
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.89LOEUF
pLI 0.024
Z-score -0.07
OE 1.05 (0.38–1.89)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.52Z-score
OE missense 1.24 (0.98–1.59)
46 obs / 37.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.05 (0.38–1.89)
0≤0.351.4
Missense OE?1.24 (0.98–1.59)
0≤0.61.4
Synonymous OE?1.21
0≤1.21.6
LoF obs/exp: 2 / 1.9Missense obs/exp: 46 / 37.0Syn Z: -0.64

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SNHG32 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients