SNHG28

Chr 1

small nucleolar RNA host gene 28

Also known as: C1orf204, VSIG8-OT1

NCBI Gene: 284677ENSG00000188004UniProt: P0DPA3

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.83
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.83LOEUF
pLI 0.000
Z-score -0.59
OE 1.21 (0.76–1.83)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.59Z-score
OE missense 0.84 (0.71–1.00)
91 obs / 108.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.21 (0.76–1.83)
0≤0.351.4
Missense OE?0.84 (0.71–1.00)
0≤0.61.4
Synonymous OE?0.85
0≤1.21.6
LoF obs/exp: 11 / 9.1Missense obs/exp: 91 / 108.3Syn Z: 0.81

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SNHG28 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients