SNHG18

Chr 5

small nucleolar RNA host gene 18

NCBI Gene: 100505806ENSG00000250786
43
ClinVar variants
41
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— SNHG18
📋
ClinVar Variants
41 Pathogenic / Likely Pathogenic of 43 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

43 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic41
Likely Benign2
41
Pathogenic
2
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————41
Likely Pathogenic
————0
VUS
————0
Likely Benign
————2
Benign
————0
Total—43

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

SNHG18 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia.
Niu K et al.·Cardiovasc Res
2024
Upregulation of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 Promotes Radioresistance of Glioma by Repressing Semaphorin 5A.
Zheng R et al.·Int J Radiat Oncol Biol Phys
2016
MKL1-induced lncRNA SNHG18 drives the growth and metastasis of non-small cell lung cancer via the miR-211-5p/BRD4 axis.
Fan H et al.·Cell Death Dis
2021
High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor Prognosis in Multiple Myeloma.
Huang LJ et al.·Acta Haematol
2020
Mutation-derived, genomic instability-associated lncRNAs are prognostic markers in gliomas.
Li S et al.·PeerJ
2023
Profiling pro-neural to mesenchymal transition identifies a lncRNA signature in glioma.
Liang Q et al.·J Transl Med
2020
Coronary artery disease-associated variants regulate vascular smooth muscle cell gene expression.
Barbera N et al.·Nat Cardiovasc Res
2025
SNHG18 deficiency reprograms arginine metabolism to foster an immunosuppressive microenvironment in prostate cancer bone metastasis.
Xie Z et al.·Cancer Lett
2026
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools