SNHG14

Chr 15

small nucleolar RNA host gene 14

Also known as: 115HG, IC-SNURF-SNRPN, LNCAT, NCRNA00214, U-UBE3A-ATS, UBE3A-AS, UBE3A-AS1, UBE3A-ATS

NCBI Gene: 104472715ENSG00000224078

This gene is located within the Prader-Willi critical region and produces a long, spliced paternally-imprinted RNA that initiates within a common upstream promoter region shared by the SNRPN (small nuclear ribonucleoprotein polypeptide N) and SNURF genes. This transcript serves as a host RNA for the small nucleolar RNA, C/D box 115 and 116 clusters. This RNA extends in antisense into the region of the ubiquitin protein ligase E3A gene (UBE3A), and is thought to regulate imprinted expression of UBE3A in the brain. This transcript undergoes extensive alternative splicing, and may initiate and terminate at multiple locations within this genomic region. The full-length structure of all splice forms is not determined. [provided by RefSeq, Mar 2017]

1299
ClinVar variants
90
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— SNHG14
📋
ClinVar Variants
90 Pathogenic / Likely Pathogenic· 249 VUS of 1299 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

1299 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic50
Likely Pathogenic40
VUS249
Likely Benign132
Benign6
Conflicting3
50
Pathogenic
40
Likely Pathogenic
249
VUS
132
Likely Benign
6
Benign
3
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
23
2
25
0
50
Likely Pathogenic
15
14
11
0
40
VUS
4
233
11
1
249
Likely Benign
2
1
33
96
132
Benign
0
2
2
2
6
Conflicting
—3
Total442528299480

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

SNHG14 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript.
Dindot SV et al.·Sci Transl Med
2023
LncRNA SNHG14 promotes proliferation of endometrial cancer through regulating microRNA-655-3p.
Wang GF et al.·Eur Rev Med Pharmacol Sci
2020
LncRNA SNHG14 silencing attenuates the progression of diabetic nephropathy via the miR-30e-5p/SOX4 axis.
Wang Y et al.·J Diabetes
2024
LncRNA SNHG14 Served as a Biomarker of Depression Disorder Patients and Regulated Depression-Like Behaviors via MiR-200a-3p.
Wang H et al.·Tohoku J Exp Med
2024Cohort
Long non-coding RNA SNHG14 induces trastuzumab resistance of breast cancer via regulating PABPC1 expression through H3K27 acetylation.
Dong H et al.·J Cell Mol Med
2018
Prognostic Significance of Long Non Coding RNA ANRIL and SNHG14 in Acute Myeloid Leukemia.
Gamaleldin MA et al.·Asian Pac J Cancer Prev
2021
Upregulation of SNHG14 suppresses cell proliferation and metastasis of colorectal cancer by targeting miR-92b-3p.
Zhang W et al.·J Cell Biochem
2020
SNHG14 lncRNA as a Prognostic Biomarker in Adult Non-M3 AML Patients.
Seifpour S et al.·Hematol Oncol Stem Cell Ther
2025Cohort
Long non-coding RNA SNHG14 exerts oncogenic functions in non-small cell lung cancer through acting as an miR-340 sponge.
Zhang Z et al.·Biosci Rep
2019
Highly expressed long non-coding RNA SNHG14 activated MSU-induced inflammatory response in acute gout arthritis through targeting miR-223-3p.
Yang L et al.·Int J Rheum Dis
2023
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools