SNHG1

Chr 11

small nucleolar RNA host gene 1

Also known as: LINC00057, NCRNA00057, U22HG, UHG, lncRNA16

NCBI Gene: 23642ENSG00000255717

This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]

17
ClinVar variants
11
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— SNHG1
📋
ClinVar Variants
11 Pathogenic / Likely Pathogenic· 4 VUS of 17 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

17 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic8
Likely Pathogenic3
VUS4
Likely Benign1
Conflicting1
8
Pathogenic
3
Likely Pathogenic
4
VUS
1
Likely Benign
1
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————8
Likely Pathogenic
————3
VUS
————4
Likely Benign
————1
Benign
————0
Conflicting
—1
Total—17

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

SNHG1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Long non-coding SNHG1 in cancer.
Thin KZ et al.·Clin Chim Acta
2019Review
Induction of m(6)A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance.
Wang Z et al.·J Exp Clin Cancer Res
2022
The prognostic value of lncRNA SNHG1 in cancer patients: a meta-analysis.
Dong B et al.·BMC Cancer
2019Meta-analysis
SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer.
Zielske SP et al.·BMC Cancer
2023
LncRNA SNHG1 promotes nasopharyngeal carcinoma development via targeting miR-424-5p.
Zhou Z et al.·Histol Histopathol
2023
Exploring the expression of SNHG1 and its effect on the PI3K-AKT axis in nasopharyngeal cancer.
Yang Y et al.·Neoplasma
2023
Cryotherapy Attenuates Inflammation via the lncRNA SNHG1/miR-9-5p/NFKB1 Regulatory Axis in Periodontal Ligament Cells.
Lin C et al.·Int J Mol Sci
2023
SNHG1/miR-145-5p/KLF5 Axis Participates in Regulating the Proliferation and Migration of Oral Squamous Cell Cancer.
Xin H et al.·J Healthc Eng
2022
The Prognostic Value of Expression of the Long Noncoding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) in Patients with Solid Malignant Tumors: A Systematic Review and Meta-Analysis.
Xiao B et al.·Med Sci Monit
2018Meta-analysis
Expression analysis of mTOR-associated lncRNAs in multiple sclerosis.
Akbari M et al.·Metab Brain Dis
2022
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Exosome-transmitted long noncoding RNA SNHG1 promotes prostate cancer bone metastasis via YBX1/MMP16 axis.
Yang T et al.·Cell Death Discov
2026🔓 Open Access
Inflammation-induced LncRNA SNHG1 orchestrates spermatogonium development in non-obstructive azoospermia via IL-17 A signaling pathway.
Zhu Y et al.·Cell Mol Life Sci
2026🔓 Open Access
LncRNA SNHG1 Knockdown Ameliorates HIV-1 gp120V3 Loop-Induced Microglial Neuroinflammation by Regulating the Autophagy Process.
Yan X et al.·Inflammation
2026🔓 Open Access
Biomimetic cancer cell membrane-coated liposomal nanocarriers loaded with silibinin suppress gastric cancer progression via SNHG1/miR-383-5p/HSP90AA1 axis-mediated PI3K/AKT pathway inhibition.
Yao J et al.·Mater Today Bio
2026🔓 Open Access
Predictive value of circulating SNHG1/miR-194-5p and carotid ultrasound for the onset of cerebral infarction in patients with transient cerebral ischemia.
Wang W et al.·Front Mol Neurosci
2025🔓 Open AccessCohort
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools