SMYD4
Chr 17SET and MYND domain containing 4
Also known as: ZMYND21
Enables protein-lysine N-methyltransferase activity. Involved in heart development. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jun 2026]
ResearchGenerating clinical summary…
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.08LOEUF
pLI 0.000
Z-score 1.21
OE 0.78 (0.57–1.08)
Highly tolerant — LoF variants common in population
Missense Constraint?
-0.01Z-score
OE missense 1.00 (0.93–1.08)
462 obs / 461.5 exp
Tolerant to missense variation
Observed / Expected Ratios?
LoF OE?0.78 (0.57–1.08)
0≤0.351.4
Missense OE?1.00 (0.93–1.08)
0≤0.61.4
Synonymous OE?0.98
0≤1.21.6
LoF obs/exp: 26 / 33.5Missense obs/exp: 462 / 461.5Syn Z: 0.23
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
SMYD4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools