SMR3B

Chr 4

submaxillary gland androgen regulated protein 3B

Also known as: P-B, PBII, PRL3, PROL3, SMR1B

NCBI Gene: 10879 ENSG00000171201 UniProt: P02814

The SMR3B protein is predicted to function as an endopeptidase inhibitor that regulates peptidase activity and may be involved in pain perception. This gene is not highly constrained against loss-of-function variants and no definitive disease associations have been established in the current datasets. Clinical significance of SMR3B variants in pediatric neurological conditions remains to be determined.

ResearchSummary from RefSeq

Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in cellular response to lipopolysaccharide; negative regulation of peptidase activity; and regulation of sensory perception of pain. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.74

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

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