SLCO4A1

Chr 20

solute carrier organic anion transporter family member 4A1

Also known as: OATP-E, OATP4A1, OATPE, OATPRP1, POAT, SLC21A12

NCBI Gene: 28231ENSG00000101187UniProt: Q96BD0

Enables prostaglandin transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Located in cell junction. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
15
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.00
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.00LOEUF
pLI 0.000
Z-score 1.56
OE 0.69 (0.48–1.00)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.43Z-score
OE missense 0.94 (0.87–1.02)
437 obs / 463.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.69 (0.48–1.00)
0≤0.351.4
Missense OE?0.94 (0.87–1.02)
0≤0.61.4
Synonymous OE?1.09
0≤1.21.6
LoF obs/exp: 20 / 29.1Missense obs/exp: 437 / 463.1Syn Z: -1.09

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SLCO4A1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients