SLCO1B7

Chr 12

solute carrier organic anion transporter family member 1B7 (putative)

Also known as: LST-3, LST-3TM12, LST3, OATP1B7, SLC21A21

NCBI Gene: 338821ENSG00000205754UniProt: G3V0H7OMIM: 619875

Predicted to enable bile acid transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.74
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.74LOEUF
pLI 0.000
Z-score -1.50
OE 1.32 (1.00–1.74)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.96Z-score
OE missense 1.15 (1.06–1.26)
357 obs / 309.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.32 (1.00–1.74)
0≤0.351.4
Missense OE?1.15 (1.06–1.26)
0≤0.61.4
Synonymous OE?1.23
0≤1.21.6
LoF obs/exp: 34 / 25.8Missense obs/exp: 357 / 309.4Syn Z: -1.85

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SLCO1B7 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients