SLC45A4

Chr 8

solute carrier family 45 member 4

NCBI Gene: 57210 ENSG00000022567 UniProt: Q5BKX6 OMIM: 619581

The SLC45A4 protein is a neuronal polyamine transporter that transports putrescine, cadaverine, spermine and spermidine in sensory neurons within the dorsal root ganglion, where it regulates the excitability of pain-sensing C-polymodal nociceptors. This gene is highly intolerant to loss-of-function variants (pLI nearly 1.0) but no established human disease associations have been reported to date. The inheritance pattern for potential SLC45A4-related disorders would be expected to be autosomal recessive given the high constraint against heterozygous loss-of-function.

OMIM ResearchSummary from RefSeq, UniProt

Enables putrescine transmembrane transporter activity; spermidine transmembrane transporter activity; and spermine transmembrane transporter activity. Involved in sensory perception of pain. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.71

LOEUF

Multiple*

Mechanism· predicted