SLC39A10

Chr 2

solute carrier family 39 member 10

ENSG00000196950UniProt: Q9ULF5

Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity)

0
ClinVar variants
0
Pathogenic / LP
0.99
pLI score· haploinsufficient
0
Active trials
Clinical Summary— SLC39A10
⚡
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 0.99). One damaged copy is likely sufficient to cause disease.
Some data sources returned errors (1)

ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
LoF intolerant — likely haploinsufficient
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
0.28LOEUF
pLI 0.993
Z-score 4.37
OE 0.11 (0.05–0.28)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
1.95Z-score
OE missense 0.74 (0.68–0.81)
334 obs / 450.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.11 (0.05–0.28)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.74 (0.68–0.81)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.1.00
0≤1.21.6
LoF obs/exp: 3 / 27.9Missense obs/exp: 334 / 450.7Syn Z: -0.01

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SLC39A10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway.
Li H et al.·J Exp Clin Cancer Res
2021
Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival.
Gao H et al.·Proc Natl Acad Sci U S A
2017
Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response.
Davis CN et al.·Neuropsychopharmacology
2025Meta-analysis
Large-Scale Analysis Reveals Gene Signature for Survival Prediction in Primary Glioblastoma.
Prasad B et al.·Mol Neurobiol
2020
Alterations in gene expressions of Caco-2 cell responses to LPS and ploy(I:C) stimulation.
Qin G et al.·PeerJ
2023
Bioinformatic analysis reveals an exosomal miRNA-mRNA network in colorectal cancer.
Ma J et al.·BMC Med Genomics
2021
Role of miR-30a-3p Regulation of Oncogenic Targets in Pancreatic Ductal Adenocarcinoma Pathogenesis.
Shimomura H et al.·Int J Mol Sci
2020
Application of laser capture microdissection and differential display technique for screening of pathogenic genes involved in endometrial carcinoma.
Wen-Xin L et al.·Int J Gynecol Cancer
2007Case report
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Nutrigenomic profiling identifies ZIP10 (SLC39A10) as a regulator of erythroid zinc homeostasis with genetic associations to anemia risk.
Kim J et al.·Proc Natl Acad Sci U S A
2026🔓 Open Access
SLC39A10 drives M2 macrophage polarization and gastric cancer progression through the MAPK14(p38α) pathway.
Liang Y et al.·iScience
2026🔓 Open Access
The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice.
Kageyama A et al.·Elife
2025🔓 Open Access
Porphyromonas gingivalis-induced HuR upregulation suppresses SLC39A10-derived hsa_circ_0057552 in esophageal squamous cell carcinoma.
Yang R et al.·Microbes Infect
2025
Endometrial zinc transporter Slc39a10/Zip10 is indispensable for progesterone responsiveness and successful pregnancy in mice.
Kawata Y et al.·PNAS Nexus
2025🔓 Open Access
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools