SLC17A9

Chr 20

solute carrier family 17 member 9

Also known as: C20orf59, POROK8, VNUT

This gene encodes a member of a family of transmembrane proteins that are involved in the transport of small molecules. The encoded protein participates in the vesicular uptake, storage, and secretion of adenoside triphosphate (ATP) and other nucleotides. A mutation in this gene was found in individuals with autosomal dominant disseminated superficial actinic porokeratosis-8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtPorokeratosis 8, disseminated superficial actinic type
0
Active trials
9
Pubs (1 yr)
P/LP submissions
P/LP missense
1.39
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.39LOEUF
pLI 0.000
Z-score 0.03
OE 0.99 (0.721.39)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.29Z-score
OE missense 0.78 (0.690.87)
204 obs / 262.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.99 (0.721.39)
00.351.4
Missense OE?0.78 (0.690.87)
00.61.4
Synonymous OE?1.08
01.21.6
LoF obs/exp: 25 / 25.1Missense obs/exp: 204 / 262.8Syn Z: -0.73

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

SLC17A9 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →