SLC16A10

Chr 6

solute carrier family 16 member 10

Also known as: MCT10, PRO0813, TAT1

NCBI Gene: 117247ENSG00000112394UniProt: Q8TF71

SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
14
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.54
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.54LOEUF
pLI 0.309
Z-score 2.93
OE 0.23 (0.12–0.54)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
1.74Z-score
OE missense 0.70 (0.62–0.79)
190 obs / 270.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.23 (0.12–0.54)
0≤0.351.4
Missense OE?0.70 (0.62–0.79)
0≤0.61.4
Synonymous OE?0.82
0≤1.21.6
LoF obs/exp: 4 / 17.0Missense obs/exp: 190 / 270.8Syn Z: 1.42

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SLC16A10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients