SLC10A4

Chr 4

solute carrier family 10 member 4

Also known as: P4

NCBI Gene: 201780ENSG00000145248UniProt: Q96EP9OMIM: 618563

Predicted to enable symporter activity. Predicted to be involved in bile acid and bile salt transport and regulation of neurotransmitter loading into synaptic vesicle. Predicted to act upstream of or within adult behavior and response to xenobiotic stimulus. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.93
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.93LOEUF
pLI 0.028
Z-score 1.72
OE 0.41 (0.20–0.93)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.00Z-score
OE missense 0.81 (0.72–0.92)
187 obs / 229.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.41 (0.20–0.93)
0≤0.351.4
Missense OE?0.81 (0.72–0.92)
0≤0.61.4
Synonymous OE?0.87
0≤1.21.6
LoF obs/exp: 4 / 9.8Missense obs/exp: 187 / 229.5Syn Z: 1.06

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SLC10A4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients