SLC10A3
Chr Xsolute carrier family 10 member 3
Also known as: DXS253E, P3
The protein encoded by this X-linked gene appears to have essential housekeeping functions based on its ubiquitous expression and evolutionary conservation across species. The gene shows moderate intolerance to loss-of-function variants (pLI 0.81), suggesting haploinsufficiency may be pathogenic, though specific disease associations and clinical phenotypes have not been established. X-linked inheritance would be expected for pathogenic variants in this gene.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
SLC10A3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools