SLAMF9

Chr 1

SLAM family member 9

Also known as: CD2F-10, CD2F10, CD84-H1, CD84H1, SF2001

This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

ResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
P/LP submissions
P/LP missense
1.28
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.28LOEUF
pLI 0.000
Z-score 0.87
OE 0.73 (0.441.28)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.11Z-score
OE missense 1.03 (0.901.17)
157 obs / 153.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.73 (0.441.28)
00.351.4
Missense OE?1.03 (0.901.17)
00.61.4
Synonymous OE?1.15
01.21.6
LoF obs/exp: 9 / 12.3Missense obs/exp: 157 / 153.1Syn Z: -0.92

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

SLAMF9 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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