SIGLEC15

Chr 18

sialic acid binding Ig like lectin 15

Also known as: CD33L3, HsT1361, SIGLEC-15

NCBI Gene: 284266ENSG00000197046UniProt: Q6ZMC9

Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
24
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.87
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.87LOEUF
pLI 0.000
Z-score -0.77
OE 1.29 (0.80–1.87)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.98Z-score
OE missense 0.79 (0.69–0.91)
139 obs / 175.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.29 (0.80–1.87)
0≤0.351.4
Missense OE?0.79 (0.69–0.91)
0≤0.61.4
Synonymous OE?0.83
0≤1.21.6
LoF obs/exp: 11 / 8.6Missense obs/exp: 139 / 175.5Syn Z: 1.20

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SIGLEC15 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients