SGF29
Chr 16SAGA complex associated factor 29
Also known as: CCDC101, STAF36, TDRD29
SGF29 encodes a chromatin reader protein that recognizes trimethylated histone H3K4 and recruits histone acetyltransferase complexes to regulate gene expression and cellular stress responses. Mutations cause autosomal recessive developmental delay with seizures, microcephaly, and intellectual disability typically presenting in early childhood. The gene shows low constraint to loss-of-function variation (pLI 0.002, LOEUF 0.82), consistent with a recessive inheritance pattern.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
SGF29 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools