SERPINB2

Chr 18

serpin family B member 2

Also known as: HsT1201, PAI, PAI-2, PAI2, PLANH2

NCBI Gene: 5055 ENSG00000197632 UniProt: P05120

The SERPINB2 protein inhibits urokinase-type plasminogen activator, functioning as a serine protease inhibitor involved in regulating fibrinolysis and apoptosis. Mutations cause plasminogen activator inhibitor-2 deficiency, inherited in an autosomal recessive pattern. This gene shows very low constraint against loss-of-function variants, which is consistent with recessive inheritance where heterozygous carriers are typically unaffected.

ResearchSummary from RefSeq, UniProt

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in fibrinolysis and negative regulation of apoptotic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.53

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)