SERPINB10

Chr 18

serpin family B member 10

Also known as: PI-10, PI10

NCBI Gene: 5273ENSG00000242550UniProt: P48595

This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]

ResearchGenerating clinical summary…
0
Active trials
4
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.47
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.47LOEUF
pLI 0.000
Z-score 0.17
OE 0.95 (0.64–1.47)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.97Z-score
OE missense 1.19 (1.07–1.33)
239 obs / 200.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.95 (0.64–1.47)
0≤0.351.4
Missense OE?1.19 (1.07–1.33)
0≤0.61.4
Synonymous OE?1.13
0≤1.21.6
LoF obs/exp: 15 / 15.7Missense obs/exp: 239 / 200.3Syn Z: -0.89

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SERPINB10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients