SDR42E2

Chr 16

short chain dehydrogenase/reductase family 42E, member 2

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. [provided by Alliance of Genome Resources, Jul 2025]

GeneReviewsResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.62
LOEUF
DN
Mechanism· predicted
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GeneReview available — SDR42E2
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.62LOEUF
pLI 0.000
Z-score -0.04
OE 1.01 (0.651.62)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.19Z-score
OE missense 0.69 (0.580.83)
84 obs / 121.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.01 (0.651.62)
00.351.4
Missense OE?0.69 (0.580.83)
00.61.4
Synonymous OE?0.94
01.21.6
LoF obs/exp: 12 / 11.9Missense obs/exp: 84 / 121.0Syn Z: 0.31

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

SDR42E2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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