SCRN3

Chr 2

secernin 3

Also known as: SES3

NCBI Gene: 79634ENSG00000144306UniProt: Q0VDG4OMIM: 614967

Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in detection of temperature stimulus involved in sensory perception of pain. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
LOEUF 1.14
Clinical Summary— SCRN3
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.14LOEUF
pLI 0.000
Z-score 1.11
OE 0.72 (0.47–1.14)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.02Z-score
OE missense 1.00 (0.90–1.12)
219 obs / 218.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.72 (0.47–1.14)
0≤0.351.4
Missense OE?1.00 (0.90–1.12)
0≤0.61.4
Synonymous OE?0.82
0≤1.21.6
LoF obs/exp: 13 / 18.1Missense obs/exp: 219 / 218.0Syn Z: 1.20

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SCRN3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients