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SCAR4

Chr 1AR

vacuolar protein sorting 13 homolog D

Also known as: BLTP5D, SCA24, SCAR4, SCASI

This gene encodes a protein belonging to the vacuolar-protein-sorting-13 family that is involved in trafficking membrane proteins between the trans-Golgi network and prevacuolar compartments. Mutations cause spinocerebellar ataxia, autosomal recessive 4, which primarily affects the cerebellum and causes progressive ataxia. The condition follows an autosomal recessive inheritance pattern.

GeneReviewsOMIMResearchSummary from RefSeq, OMIM
AR1 OMIM phenotype
📖
GeneReview available — SCAR4
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/SCAR4?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

SCAR4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found