SCAND3

Chr 6

SCAN domain containing 3

Also known as: Buster4, FAM200D, ZBED9, ZFP38-L, ZNF305P2, ZNF452, dJ1186N24.3

NCBI Gene: 114821ENSG00000232040UniProt: Q6R2W3

Predicted to enable nucleic acid binding activity. Involved in positive regulation of cell cycle and positive regulation of epithelial cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.67
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.67LOEUF
pLI 0.000
Z-score 3.36
OE 0.47 (0.34–0.67)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
2.39Z-score
OE missense 0.74 (0.69–0.80)
495 obs / 668.9 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.47 (0.34–0.67)
0≤0.351.4
Missense OE?0.74 (0.69–0.80)
0≤0.61.4
Synonymous OE?0.80
0≤1.21.6
LoF obs/exp: 22 / 46.8Missense obs/exp: 495 / 668.9Syn Z: 2.42

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SCAND3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients