S100A8
Chr 1S100 calcium binding protein A8
Also known as: 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MRP8
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
S100A8 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human
ACTIVE NOT RECRUITINGMicrobiome and Enteric Signatures in Sepsis-associated Hepatorenal Injury
RECRUITINGAssessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
ACTIVE NOT RECRUITINGEffect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes
RECRUITINGEvidence Based Probiotic Therapy of Proton Pump Inhibitor Induced Dysbiosis
ACTIVE NOT RECRUITINGRegulation of Mucosal Healing in Inflammatory Bowel Disease
RECRUITINGPilot Study of a Modified Therapeutic Food Compared With a Standard Nutrient Supplement in Young Children in Rural Guatemala
NOT YET RECRUITINGPredicting IBD Treatment Outcomes With Gut Microbiome Analysis
RECRUITINGMaternal Probiotic Intervention to Improve Gut Health-Trial II-Pakistan
RECRUITINGEffect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial)
RECRUITINGGoat Milk-Derived Formula vs. Undiluted Goat Milk in Infants Unable to Exclusively Breastfeed: Growth and Biomarker Analysis
RECRUITINGThe Impact of Acupuncture on Biomarkers of Brain Injury and Inflammatory Response in Migraine
ACTIVE NOT RECRUITINGExternal Resources
Links to major genomics databases and tools