S100A7A

Chr 1

S100 calcium binding protein A7A

Also known as: NICE-2, NICE2, S100A15, S100A7L1, S100A7f

NCBI Gene: 338324ENSG00000184330UniProt: Q86SG5

Enables identical protein binding activity. Predicted to be involved in endothelial cell migration. Predicted to act upstream of or within inflammatory response. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
8
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.94
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.94LOEUF
pLI 0.003
Z-score -1.02
OE 1.87 (0.63–1.94)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.27Z-score
OE missense 1.47 (1.24–1.76)
84 obs / 57.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.87 (0.63–1.94)
0≤0.351.4
Missense OE?1.47 (1.24–1.76)
0≤0.61.4
Synonymous OE?1.33
0≤1.21.6
LoF obs/exp: 3 / 1.6Missense obs/exp: 84 / 57.0Syn Z: -1.28

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

S100A7A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients