RXFP4
Chr 1relaxin family peptide/INSL5 receptor 4
Also known as: GPCR142, GPR100, RLN3R2, RXFPR4
GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
ResearchGenerating clinical summary…
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.70LOEUF
pLI 0.000
Z-score 0.04
OE 0.98 (0.57–1.70)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.66Z-score
OE missense 0.88 (0.79–0.99)
209 obs / 237.4 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.98 (0.57–1.70)
0≤0.351.4
Missense OE?0.88 (0.79–0.99)
0≤0.61.4
Synonymous OE?0.80
0≤1.21.6
LoF obs/exp: 8 / 8.1Missense obs/exp: 209 / 237.4Syn Z: 1.61
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RXFP4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools