RWDD2A
Chr 6RWD domain containing 2A
Also known as: RWDD2, dJ747H23.2
LOEUF 1.62
Clinical Summary— RWDD2A
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Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.62LOEUF
pLI 0.000
Z-score 0.08
OE 0.97 (0.60–1.62)
Highly tolerant — LoF variants common in population
Missense Constraint?
1.07Z-score
OE missense 0.76 (0.65–0.88)
115 obs / 152.3 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.97 (0.60–1.62)
0≤0.351.4
Missense OE?0.76 (0.65–0.88)
0≤0.61.4
Synonymous OE?1.00
0≤1.21.6
LoF obs/exp: 10 / 10.3Missense obs/exp: 115 / 152.3Syn Z: 0.01
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RWDD2A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools