RTN4RL2

Chr 11

reticulon 4 receptor like 2

Also known as: NGRH1, NgR2

NCBI Gene: 349667 ENSG00000186907 UniProt: Q86UN3 OMIM: 610462

Enables signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; negative regulation of neuron projection development; and positive regulation of synapse assembly. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

OMIM Research

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

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LOEUF

GOF

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in RTN4RL2?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 170

527 rare PASS variants

Rare truncating (LoF)

1 in 1,700

51 rare PASS variants

Rare synonymous (reference)

1 in 150

321 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for RTN4RL2. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 250	1 in 2,500
South Asian	~43k	1 in 120	1 in 480
Remaining (unassigned)	~30k	1 in 130	1 in 1,700
European (Finnish)	~27k	1 in 210	1 in 850
Admixed American	~22k	1 in 120	1 in 290
African / African American	~21k	1 in 130	1 in 1,200
East Asian	~20k	1 in 110	1 in 1,200
Ashkenazi Jewish	~13k	1 in 420	1 in 820
Middle Eastern	~2,884	1 in 150	≈ 1 in 2,800

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 2 of 3 coding exons well covered in gnomAD exomes; exon 1 marginal. Genomes: all 3.? see exons ↓