RTN4RL1
Chr 17reticulon 4 receptor like 1
Also known as: NGRH2, NgR3
The protein functions as a cell surface receptor that regulates axon regeneration in the central nervous system, contributes to corpus callosum formation, and restricts dendritic spine and synapse formation during brain development. Mutations cause autosomal recessive spastic paraplegia with intellectual disability and corpus callosum abnormalities. This gene is highly constrained against loss-of-function variants, indicating that complete loss of protein function is likely incompatible with normal development.
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RTN4RL1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools