RSPH9

Chr 6

radial spoke head component 9

Also known as: C6orf206, CILD12, MRPS18AL1

This gene encodes a protein thought to be a component of the radial spoke head in motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia 12. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

GeneReviewsResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtCiliary dyskinesia, primary, 12

Clinical highlights

Gene-disease validity (ClinGen)
primary ciliary dyskinesia 12 · ARDefinitivesufficient evidence for diagnostic panels
0
Active trials
9
Pubs (1 yr)
P/LP submissions
P/LP missense
1.63
LOEUF
Mechanism
📖
GeneReview available — RSPH9
Authoritative clinical overview · Recommended first read
Open GeneReview ↗
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.63LOEUF
pLI 0.000
Z-score -0.12
OE 1.04 (0.671.63)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.24Z-score
OE missense 0.95 (0.831.08)
164 obs / 172.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.04 (0.671.63)
00.351.4
Missense OE?0.95 (0.831.08)
00.61.4
Synonymous OE?0.97
01.21.6
LoF obs/exp: 13 / 12.6Missense obs/exp: 164 / 172.8Syn Z: 0.18

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

RSPH9 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →