RPP38
Chr 10ribonuclease P/MRP subunit p38
This protein is a component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends, and also participates in the MRP ribonuclease complex involved in pre-rRNA processing. Based on the provided data, no specific diseases have been definitively associated with RPP38 mutations. The gene shows low constraint against loss-of-function variants (pLI 0.0002, LOEUF 1.615), suggesting that heterozygous loss-of-function mutations may be tolerated.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RPP38 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools