RPL41

Chr 12

ribosomal protein L41

Also known as: L41, eL41

NCBI Gene: 6171ENSG00000229117UniProt: P62945OMIM: 613315

Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in cytoplasmic translation. Located in endoplasmic reticulum. Part of cytosolic large ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
9
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.60
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.60LOEUF
pLI 0.184
Z-score 0.90
OE 0.39 (0.14–1.60)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.72Z-score
OE missense 0.42 (0.22–0.88)
5 obs / 12.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.39 (0.14–1.60)
0≤0.351.4
Missense OE?0.42 (0.22–0.88)
0≤0.61.4
Synonymous OE?1.66
0≤1.21.6
LoF obs/exp: 1 / 2.6Missense obs/exp: 5 / 12.0Syn Z: -0.90

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

RPL41 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients