RPL36A-HNRNPH2

Chr X

RPL36A-HNRNPH2 readthrough

This read-through transcript between ribosomal protein L36a and heterogeneous nuclear ribonucleoprotein H2 genes produces a protein similar to ribosomal protein L36a, which functions in protein synthesis as part of the ribosomal machinery. The gene is not highly constrained against loss-of-function variants and no established disease associations have been reported in the provided data. The locus is located on chromosome X.

ResearchSummary from RefSeq

This locus represents naturally occurring read-through transcription between the neighboring ribosomal protein L36a and heterogeneous nuclear ribonucleoprotein H2 (H') genes on chromosome X. The read-through transcript produces a protein with similarity to the protein encoded by the upstream locus, ribosomal protein L36a. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2011]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.01

LOEUF

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Mechanism

Some data sources returned errors (1)

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