RPL10

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit and plays a role in forming actively translating ribosomes. Mutations cause X-linked intellectual developmental disorder with syndromic features and have been associated with autism spectrum disorders, inherited in an X-linked recessive pattern. The gene shows high constraint against loss-of-function variants, suggesting mutations predominantly cause disease through haploinsufficiency or loss-of-function mechanisms.