RNVU1-15

Chr 1

RNA, variant U1 small nuclear 15

Also known as: RNU1-121, RNU1-66, RNVU1-16, vU1.15, vU1.16

NCBI Gene: 101954267ENSG00000207205

Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP. [provided by Alliance of Genome Resources, Jul 2025]

13
ClinVar variants
9
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— RNVU1-15
📋
ClinVar Variants
9 Pathogenic / Likely Pathogenic· 3 VUS of 13 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

13 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic9
VUS3
Benign1
9
Pathogenic
3
VUS
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
9
0
9
Likely Pathogenic
0
0
0
0
0
VUS
0
0
3
0
3
Likely Benign
0
0
0
0
0
Benign
0
0
1
0
1
Total0013013

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

RNVU1-15 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found

Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools