RNU4ATAC

Chr 2

RNA, U4atac small nuclear

Also known as: LWS, MOPD1, RFMN, RNU4ATAC1, TALS, U4ATAC

The small nuclear RNA (snRNA) encoded by this gene is part of the U12-dependent minor spliceosome complex. In addition to the encoded RNA, this ribonucleoprotein complex consists of U11, U12, U5, and U6atac snRNAs. The U12-dependent spliceosome acts on approximately 700 specific introns in the human genome. Defects in this gene are a cause of microcephalic osteodysplastic primordial dwarfism type 1 (MOPD). [provided by RefSeq, Jul 2011]

GeneReviewsResearchGenerating clinical summary…

Clinical highlights

Gene-disease validity (ClinGen)
RNU4ATAC spectrum disorder · ARDefinitivesufficient evidence for diagnostic panels
2
Active trials
14
Pubs (1 yr)
P/LP submissions
P/LP missense
LOEUF
Mechanism
📖
GeneReview available — RNU4ATAC
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

RNU4ATAC · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.