RNF223
Chr 1ring finger protein 223
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.87LOEUF
pLI 0.027
Z-score 0.06
OE 0.95 (0.35–1.87)
Highly tolerant — LoF variants common in population
Missense Constraint?
-0.55Z-score
OE missense 1.15 (0.99–1.33)
124 obs / 107.8 exp
Tolerant to missense variation
Observed / Expected Ratios?
LoF OE?0.95 (0.35–1.87)
0≤0.351.4
Missense OE?1.15 (0.99–1.33)
0≤0.61.4
Synonymous OE?1.15
0≤1.21.6
LoF obs/exp: 2 / 2.1Missense obs/exp: 124 / 107.8Syn Z: -0.81
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RNF223 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools