RNF151
Chr 16ring finger protein 151
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jun 2026]
ResearchGenerating clinical summary…
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.65LOEUF
pLI 0.000
Z-score 0.31
OE 0.87 (0.47–1.65)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.31Z-score
OE missense 0.93 (0.82–1.07)
154 obs / 165.2 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.87 (0.47–1.65)
0≤0.351.4
Missense OE?0.93 (0.82–1.07)
0≤0.61.4
Synonymous OE?1.20
0≤1.21.6
LoF obs/exp: 6 / 6.9Missense obs/exp: 154 / 165.2Syn Z: -1.28
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RNF151 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools