RNF151
Chr 16ring finger protein 151
RNF151 encodes a protein predicted to have zinc ion binding activity and may be involved in acrosome formation during sperm development. The gene is highly constrained against loss-of-function variation (pLI = 0.0002), suggesting that mutations would likely be pathogenic, but no specific human diseases have been definitively associated with RNF151 variants to date. Given the predicted role in spermatogenesis and high constraint, mutations might be expected to cause male infertility or broader developmental disorders.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
The highest-scoring mechanism for this gene is gain-of-function.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RNF151 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools