RNF150

Chr 4

ring finger protein 150

NCBI Gene: 57484ENSG00000170153UniProt: Q9ULK6OMIM: 621628

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.82
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.82LOEUF
pLI 0.001
Z-score 2.11
OE 0.46 (0.27–0.82)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.97Z-score
OE missense 0.83 (0.74–0.93)
220 obs / 264.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.46 (0.27–0.82)
0≤0.351.4
Missense OE?0.83 (0.74–0.93)
0≤0.61.4
Synonymous OE?1.06
0≤1.21.6
LoF obs/exp: 8 / 17.6Missense obs/exp: 220 / 264.4Syn Z: -0.48

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

RNF150 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients