RNF139
Chr 8ring finger protein 139
LOEUF 0.441 OMIM phenotype
Clinical Summary— RNF139
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Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.54) — some intolerance to loss-of-function variants.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?
0.44LOEUF
pLI 0.538
Z-score 3.59
OE 0.21 (0.11–0.44)
More LoF-intolerant than ~75% of genes
Missense Constraint?
1.84Z-score
OE missense 0.73 (0.66–0.81)
261 obs / 359.2 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.21 (0.11–0.44)
0≤0.351.4
Missense OE?0.73 (0.66–0.81)
0≤0.61.4
Synonymous OE?1.10
0≤1.21.6
LoF obs/exp: 5 / 24.0Missense obs/exp: 261 / 359.2Syn Z: -0.89
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RNF139 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools