RNF11
Chr 1ring finger protein 11
Also known as: CGI-123, SID1669
RNF11 encodes a RING-H2 finger protein that functions as an essential component of a ubiquitin-editing complex that terminates inflammatory signaling pathways by promoting RIPK1 degradation and downregulating NF-kappa-B activation. The gene shows significant constraint against loss-of-function variants (LOEUF 0.69), but pathogenic variants and associated human disease phenotypes have not yet been established. RNF11 expression is induced by mutant RET proteins associated with multiple endocrine neoplasia, suggesting potential involvement in endocrine signaling pathways.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
The highest-scoring mechanism for this gene is gain-of-function.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RNF11 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools