RN7SK

Chr 6

RNA component of 7SK nuclear ribonucleoprotein

Also known as: 7SK

Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Jul 2025]

12
ClinVar variants
9
Pathogenic / LP
pLI score
0
Active trials
Clinical SummaryRN7SK
📋
ClinVar Variants
9 Pathogenic / Likely Pathogenic· 3 VUS of 12 total submissions
Some data sources returned errors (1)

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Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

12 submitted variants in ClinVar

Classification Summary

Pathogenic7
Likely Pathogenic2
VUS3
7
Pathogenic
2
Likely Pathogenic
3
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
7
Likely Pathogenic
2
VUS
3
Likely Benign
0
Benign
0
Total12

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

RN7SK · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
The impact of non-coding RNAs on macrophage polarization.
Ghafouri-Fard S et al.·Biomed Pharmacother
2021Review
Top 10 resultsSearch PubMed ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →