RMND1

Chr 6AR

required for meiotic nuclear division 1 homolog

Also known as: C6orf96, COXPD11, RMD1, bA351K16, bA351K16.3

The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

GeneReviewsOMIMResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

Combined oxidative phosphorylation deficiency 11MIM #614922
AR

Clinical highlights

Gene-disease validity (ClinGen)
mitochondrial disease · ARDefinitivesufficient evidence for diagnostic panels
0
Active trials
6
Pubs (1 yr)
P/LP submissions
P/LP missense
1.11
LOEUF
DN
Mechanism· predicted
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GeneReview available — RMND1
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.11LOEUF
pLI 0.000
Z-score 1.17
OE 0.74 (0.501.11)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.77Z-score
OE missense 0.86 (0.770.97)
201 obs / 233.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.74 (0.501.11)
00.351.4
Missense OE?0.86 (0.770.97)
00.61.4
Synonymous OE?1.01
01.21.6
LoF obs/exp: 17 / 23.0Missense obs/exp: 201 / 233.9Syn Z: -0.04

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

RMND1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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