RIMBP3C

Chr 22

RIMS binding protein 3C

Also known as: RIM-BP3.3, RIMBP3.3

NCBI Gene: 150221ENSG00000183246UniProt: A6NJZ7

Predicted to enable benzodiazepine receptor binding activity. Predicted to be involved in fertilization and spermatid development. Predicted to be located in manchette. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

107
ClinVar variants
85
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— RIMBP3C
📋
ClinVar Variants
85 Pathogenic / Likely Pathogenic· 18 VUS of 107 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

107 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic83
Likely Pathogenic2
VUS18
Likely Benign3
Benign1
83
Pathogenic
2
Likely Pathogenic
18
VUS
3
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————83
Likely Pathogenic
————2
VUS
————18
Likely Benign
————3
Benign
————1
Total—107

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

RIMBP3C · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found

Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools