RGS5

Chr 1Multi

regulator of G protein signaling 5

Also known as: MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

OMIMResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

[Blood pressure regulation QTL]MIM #145500
Multi
0
Active trials
36
Pubs (1 yr)
P/LP submissions
P/LP missense
1.34
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.34LOEUF
pLI 0.001
Z-score 0.87
OE 0.68 (0.371.34)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.15Z-score
OE missense 0.96 (0.811.14)
91 obs / 95.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.68 (0.371.34)
00.351.4
Missense OE?0.96 (0.811.14)
00.61.4
Synonymous OE?0.69
01.21.6
LoF obs/exp: 6 / 8.8Missense obs/exp: 91 / 95.1Syn Z: 1.46

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

RGS5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →