RGS16

Chr 1

regulator of G protein signaling 16

Also known as: A28-RGS14, A28-RGS14P, RGS-R

NCBI Gene: 6004ENSG00000143333UniProt: O15492

The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
21
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.60
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.60LOEUF
pLI 0.000
Z-score 0.26
OE 0.91 (0.53–1.60)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.43Z-score
OE missense 0.89 (0.75–1.05)
100 obs / 112.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.91 (0.53–1.60)
0≤0.351.4
Missense OE?0.89 (0.75–1.05)
0≤0.61.4
Synonymous OE?0.91
0≤1.21.6
LoF obs/exp: 8 / 8.8Missense obs/exp: 100 / 112.7Syn Z: 0.50

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

RGS16 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients