RGPD8

Chr 2

RANBP2 like and GRIP domain containing 8

Also known as: RANBP2L1, RGP8, RanBP2alpha

Predicted to enable small GTPase binding activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

GeneReviewsOMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
P/LP submissions
P/LP missense
1.07
LOEUF
DN
Mechanism· predicted
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GeneReview available — RGPD8
Authoritative clinical overview · Recommended first read
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.07LOEUF
pLI 0.000
Z-score 1.34
OE 0.67 (0.441.07)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.47Z-score
OE missense 1.09 (0.981.21)
247 obs / 227.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.67 (0.441.07)
00.351.4
Missense OE?1.09 (0.981.21)
00.61.4
Synonymous OE?1.07
01.21.6
LoF obs/exp: 13 / 19.4Missense obs/exp: 247 / 227.2Syn Z: -0.53

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

RGPD8 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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