RDX
Chr 11ARradixin
Also known as: DFNB24
Radixin is a cytoskeletal protein that binds the barbed end of actin filaments to the plasma membrane, linking the actin cytoskeleton to the cell membrane. Mutations cause autosomal recessive deafness (DFNB24). The gene is highly constrained against loss-of-function variants, suggesting that complete loss of radixin function is likely pathogenic.
Definitive — sufficient evidence for diagnostic panels
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RDX · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools